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Stem Cell Therapy
Research initiatives in the Frank Hawkins Kenan Plastic Surgery Research Laboratories seek to harness the angiogenic potential of adipose derived stem cells. Pluoripotential mesenchymal stem  cells exist in readily accessible areas throughout the adult human body and under certain conditions, mesenchymal stem cells produce soluble factors which promote the growth of new blood vessels.
Through cell to cell interactions, it has been found that mesenchymal stem cells may play a role in cellular trafficking at the site of wounds and dysvascular tissue. Our research provides a better understanding of the molecular pathways which govern paracrine and cell to cell interactions necessary for adipose derived stem cell induced angiogenesis. Findings show that these efforts may be directly applicable to ischemic flaps and acellular materials.
Current Grants
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Plastic Surgery Education Foundation
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National Institutes of Health - Biosensor Biocompatibility, Heat and radiation effects in tumor microcirculation, Nitric Oxide-Releasing Glucose Biosensors, Development of a novel glaucoma implant
Lab Personnel
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Detlev Erdmann, MD, PhD, MHSc, Associate Professor
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Scott Hollenbeck, MD, Resident
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Michael Hodavance, BS, Medical student with Howard Hughes fellowship
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Bruce Klitzman, PhD, Associate Professor
- Issei Komatsu, MD, Fellow
- Nga Le, Biomedical Engineering PhD student
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Gemma Lewis, Medical student with Bollinger fellowship
Publications
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DUKE UNIVERSITY
SCHOOL OF MEDICINE
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